Neuroprotective effects of triterpenoid saponins from Medicago sativa L. against H2O2-induced oxidative stress in SH-SY5Y cells |
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| Affiliation: | 1. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;2. State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China;3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Laboratoire de Biochimie et Biologie Moléculaire, Faculté de Pharmacie, URCA, Reims, France;2. Laboratoire de Pharmacognosie, Faculté de Pharmacie, SFR Cap Santé, ICMR-CNRS UMR 7312, Reims, France;3. Service d''endocrinologie, de diabétologie et de nutrition, CHU Robert-Debré, Reims, France;4. MEDyC UMR CNRS/URCA no. 7369, Faculté des Sciences, SFR Cap Santé, URCA, Reims, France;5. MEDyC UMR CNRS/URCA no. 7369, Faculté de Pharmacie, SFR Cap Santé, URCA, Reims, Francen |
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| Abstract: | Medicago sativa L. is a forage legume plant widely distributed in all continents. Six new triterpenoid saponins, Medicagosides A-F (1–6) and five known ones (7–11) were isolated from M. sativa. Their structures were determined via HRESIMS, 1D and 2D NMR analysis. Biologically, all the isolates displayed neuroprotective activities against H2O2-induced damage in SH-SY5Y cells. Among them, compounds 1, 3–5 and 10 exhibited striking neuroprotective activities at 100 μM, restoring cell viability range from 79.66% to 89.03%, relative to 79.46% (100 μM) of Trolox used as the positive control. |
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| Keywords: | Triterpenoid saponins Neuroprotective effects SH-SY5Y cells |
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