Eight new biflavonoids with lavandulyl units from the roots of Sophora flavescens and their inhibitory effect on PTP1B |
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| Institution: | 1. Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, United States;2. Department of BioMolecular Sciences, Division of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, United States;3. Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States;4. Department of Chemistry, Yale University, New Haven, CT 06520, United States;5. Chemical Biology Institute, Yale University, West Haven, CT 06516, United States;6. College of Pharmacy, Keimyung University, Daegu 42601, Republic of Korea;7. Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, United States;8. College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea |
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| Abstract: | In the course of studying the components from the roots of Sophora flavescens, eight new unusual biflavonoids consisting of a flavanone fused with a dihydrochalcone skeleton were isolated. These new chemical structures were elucidated by means of UV, IR, HRESIMS, NMR and ECD spectroscopic data and a comparison of experimental ECD spectra with calculated ECD spectra. Some compounds were subjected to an antidiabetic bioassay on human recombinant PTP1B inhibition, and showed strong inhibitory activity. |
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| Keywords: | Biflavonoids Sophobiflavonoids A–H PTP1B inhibitory activity |
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