Bioactive monoterpene indole alkaloids from Nauclea officinalis |
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Affiliation: | 1. Department of General Practice, The Second Hospital of DaLian Medical University, DaLian 116023, China;2. Department of Experimental Medicine, Northern Hospital, Shenyang 110016, China;3. College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China;4. Department of Organic Chemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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Abstract: | Two new monoterpene indole alkaloids, naucleaoffines A (1) and B (2), together with six known alkaloids (3–8), were isolated from the stems and leaves of Nauclea officinalis. The structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with the data reported in literature. All isolated compounds were evaluated for their anti-inflammatory activities and anti-HIV-1 activities. Compounds 1–8 exhibited significant inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with IC50 values comparable to that of hydrocortisone. In addition, compounds 1–8 showed significant anti-HIV-1 activities with EC50 ranged from 0.06 to 2.08 µM. These findings suggest that the discoveries of these indole alkaloids with significant anti-inflammatory activities and anti-HIV-1 activities isolated from N. officinalis could be of great importance to the development of new anti-inflammatory and anti-HIV agents. |
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Keywords: | Monoterpene indole alkaloids Naucleaoffines A and B Nitric oxide production inhibition Anti-HIV-1 activities |
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