Meglumine as a green,efficient and reusable catalyst for synthesis and molecular docking studies of bis(indolyl)methanes as antioxidant agents |
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| Institution: | 1. Chemical Engineering Institute, Ural Federal University, Yekaterinburg 620002, Russian Federation;2. Ural Division of the Russian Academy of Sciences, I. Ya. Postovskiy Institute of Organic Synthesis, 22 S. Kovalevskoy Street, Yekaterinburg 620219, Russian Federation;3. Rajeev Gandhi Memorial College of Engineering and Technology (Autonomous), Nandyal 518501, Andhra Pradesh, India;4. Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India;5. Division of molecular biology, Department of Zoology, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India;1. Research Center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia;2. Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia;1. Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India;2. Agroprocessing and Natural Products Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India;3. Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695019, Kerala, India;1. School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China;2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China;3. School of Materials and Chemical Engineering, Chongqing University of Arts and Science, Chongqing 402160, China;1. Photochemistry Department, National Research Centre, Dokki, Cairo 12622, Egypt;2. Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt;1. Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal;2. CIQA, FCT, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal;3. CCMAR–Centre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, Faro 8005-139, Portugal;1. Department of Chemistry, Krishnath College, Berhampore, Murshidabad 742101, India;2. Department of Chemistry, Jadavpur University, Kolkata 700032, India;3. Department of Chemistry, Dr. A. P. J. Abdul Kalam Govt. College, New Town, Kolkata 700156, India |
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| Abstract: | An efficient and convenient Meglumine catalyzed procedure for the synthesis of bis(indolyl) methanes at ambient temperature under aqueous conditions in high yields. The catalytic reaction proceeds very smoothly. Clean reaction, ease of product isolation/purification, easily available reactants, metal free and environmentally friendly reaction conditions are the notable advantages of the present methodology. All the entitled compounds were characterized by IR, 1H, 13C NMR, mass spectra and evaluated for their antioxidant (DPPH, H2O2 and NO scavenging methods). They exhibited potent in vitro antioxidant activity dose-dependently. The binding interactions and molecular docking studies for entitled compounds were studied against 3MNG protein. 4d exhibited marked binding affinity with excellent docking score of ?7.6 K.cal/mol and emerged as a lead compound. |
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| Keywords: | Meglumine catalyst Antioxidant activity Molecular docking 3MNG protein |
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