Promising antibacterial agents against multidrug resistant Staphylococcus aureus |
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| Affiliation: | 1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India;2. Division of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow 226031, Uttar Pradesh, India;1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, Telangana, India;2. Division of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow, 226031, Uttar Pradesh, India;1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India;2. Division of Microbiology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Janakipuram Extension, Lucknow 226031, Uttar Pradesh, India |
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| Abstract: | Rapid emergence of multidrug resistant Staphylococcus aureus infections has created a critical health menace universally. Resistance to all the available chemotherapeutics has been on rise which led to WHO to stratify Staphylococcus aureus as high tier priorty II pathogen. Hence, discovery and development of new antibacterial agents with new mode of action is crucial to address the multidrug resistant Staphylococcus aureus infections. The egressing understanding of new antibacterials on their biological target provides opportunities for new therapeutic agents. This review underlines on various aspects of drug design, structure activity relationships (SARs) and mechanism of action of various new antibacterial agents and also covers the recent reports on new antibacterial agents with potent activity against multidrug resistant Staphylococcus aureus. This review provides attention on in vitro and in vivo pharmacological activities of new antibacterial agents in the point of view of drug discovery and development. |
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| Keywords: | Antibacterial agents Minimum inhibitory concentration Vero cells AMP" },{" #name" :" keyword" ," $" :{" id" :" k0030" }," $$" :[{" #name" :" text" ," _" :" antimicrobial peptides CPX" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" ciprofloxacin CrtN" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" Diapophytoene Desaturases Efflux Pump Inhibitors GCHMs" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" glabridin-chalcone hybrid molecules hERG" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" thehumanEther-à-go-go-RelatedGene ITQs" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" isothiazoloquinolones KPC-2" },{" #name" :" keyword" ," $" :{" id" :" k0100" }," $$" :[{" #name" :" text" ," _" :" Klebsiella pneumoniae Carbapenemase-2 LREF" },{" #name" :" keyword" ," $" :{" id" :" k0110" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" linezolid-resistant " },{" #name" :" italic" ," _" :" Enterococcus faecium MDR-SA" },{" #name" :" keyword" ," $" :{" id" :" k0120" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" multidrug resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus MRSA" },{" #name" :" keyword" ," $" :{" id" :" k0130" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus MSSA" },{" #name" :" keyword" ," $" :{" id" :" k0140" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin sensitive " },{" #name" :" italic" ," _" :" Staphylococcus aureus MRSE" },{" #name" :" keyword" ," $" :{" id" :" k0150" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin-resistant " },{" #name" :" italic" ," _" :" S. epidermidis MVRSA" },{" #name" :" keyword" ," $" :{" id" :" k0160" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" methicillin and Vancomycin-resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus MBC" },{" #name" :" keyword" ," $" :{" id" :" k0170" }," $$" :[{" #name" :" text" ," _" :" Minimum Bactericidal Concentration MK" },{" #name" :" keyword" ," $" :{" id" :" k0180" }," $$" :[{" #name" :" text" ," _" :" menaquinone NDM-1" },{" #name" :" keyword" ," $" :{" id" :" k0190" }," $$" :[{" #name" :" text" ," _" :" New Delhi metallo-beta-lactamase-1 PK" },{" #name" :" keyword" ," $" :{" id" :" k0200" }," $$" :[{" #name" :" text" ," _" :" pharmacokinetic PRSP" },{" #name" :" keyword" ," $" :{" id" :" k0210" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" penicillin-resistant " },{" #name" :" italic" ," _" :" Streptococcus pneumonia PLAs" },{" #name" :" keyword" ," $" :{" id" :" k0220" }," $$" :[{" #name" :" text" ," _" :" propargyl-linked antifolates PBP2a" },{" #name" :" keyword" ," $" :{" id" :" k0230" }," $$" :[{" #name" :" text" ," _" :" penicillin binding protein 2a PYR-NEO B" },{" #name" :" keyword" ," $" :{" id" :" k0240" }," $$" :[{" #name" :" text" ," _" :" Pyrene-Neomycin B QR-SA" },{" #name" :" keyword" ," $" :{" id" :" k0250" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" quinolone-resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus RMA" },{" #name" :" keyword" ," $" :{" id" :" k0260" }," $$" :[{" #name" :" text" ," _" :" Resistance-Modifying Agent SAR" },{" #name" :" keyword" ," $" :{" id" :" k0270" }," $$" :[{" #name" :" text" ," _" :" Structure Activity Relationship TMP" },{" #name" :" keyword" ," $" :{" id" :" k0280" }," $$" :[{" #name" :" text" ," _" :" trimethoprim TMK" },{" #name" :" keyword" ," $" :{" id" :" k0290" }," $$" :[{" #name" :" text" ," _" :" thymidylate kinase VRSA" },{" #name" :" keyword" ," $" :{" id" :" k0300" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" vancomycin resistant " },{" #name" :" italic" ," _" :" Staphylococcus aureus VRE" },{" #name" :" keyword" ," $" :{" id" :" k0310" }," $$" :[{" #name" :" text" ," _" :" Vancomycin-Resistant Enterococci WHO" },{" #name" :" keyword" ," $" :{" id" :" k0320" }," $$" :[{" #name" :" text" ," _" :" World Health Organisation |
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