1,8-Substituted anthraquinones,anthrones and bianthrones as potential non-azole leads against fungal infections |
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| Institution: | 1. School of Pharmacy, Nantong University, Nantong 226001, PR China;2. Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of education, Nanchang 330004, PR China;3. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China;4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China |
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| Abstract: | The synthesis of a variety of 1,8-substituted anthraquinones, anthrones and bianthrones and their potential as antifungal agents is evaluated. Preliminary screening against Schizosaccharomyces pombe (S. pombe), a fission yeast, and Saccharomyces cerevisiae (S. cerevisiae), a budding yeast, is reported. Both these yeast species demonstrate close homologue to a number of pathogenic fungi. |
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| Keywords: | Antifungal Anthraquinones Anthrones Bianthrones Non-azole Yeasts |
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