Structures and biological evaluation of phenylpropanoid derivatives from Murraya koenigii

Four new phenylpropanoid derivatives (1–4), together with eleven known analogues (5–15) were isolated and identified by comparison with their references and extensive spectroscopic methods from Murraya koenigii for the first time. Compounds (1–15) were assayed for their inhibitory activities by measuring IL-6-induced STAT3 promoter activities in HepG2 cells, and found compounds 1, 2, 6, and 15 showed inhibitory effects with IC₅₀ values of 11.5, 18.7, 8.9, and 22.7 μM, respectively. The inhibitory activities of compounds (1–15) were screened against NO production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells, and found compounds 3, 4, 9, 11, and 14 exhibited inhibitions against LPS-induced NO production in RAW264.7 macrophages, with IC₅₀ values of 32.7, 7.9, 42.1, 58.9, and 62.4 μM, respectively.