Synthesis,ADME, docking studies and in vivo anti-hyperglycaemic potential estimation of novel Schiff base derivatives from octadec-9-enoic acid
Affiliation:
1. Laboratory of Advanced Carbon Nanomaterials, Kazan Federal University, 18 Kremlevskaya st., 420008 Kazan, Russia;2. Department of Inorganic Chemistry, V. N. Karazin Kharkiv National University, 4 Svoboda sq., 61022 Kharkiv, Ukraine;3. Department of Chemistry, Microbiology and Hygiene of Nutrition, Kharkiv State University of Food Technology and Trade, 333 Klochkivska st., 61051 Kharkiv, Ukraine
Abstract:
A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular properties of the metabolites. Docking disquisition on co-crystallized protein of PPAR-γ (PDB ID 1FM9) was carried out which showed S21, S10 and S7 as best situated in the vital sites of receptor having docking scores −9.19, −8.68 and −8.64 respectively. Free binding energy measured using model of Maestro 9.0 and was in range of from −40.01 and −80.54 kcal/mol, significant when compared with pioglitazone (−51.58 Kcal/mol). Seven best docked derivatives were assessed for in-vivo oral glucose tolerance on normal rats and anti-hyperglycaemic activity by streptozotocin induced diabetes model. S21 unveiled to be the best measured analogue among all the synthesized entities. Encouraging outcomes motivates fatty acids for further development of more effective and safer compounds.
