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GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism |
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| Authors: | Lisha Wei Yan-Yan Zheng Jie Sun Pei Wang Tao Tao Yeqiong Li Xin Chen Yongjuan Sang Danyang Chong Wei Zhao Yuwei Zhou Ye Wang Zhihui Jiang Tiantian Qiu Chao-Jun Li Min-Sheng Zhu Xuena Zhang |
| Affiliation: | State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center and Medical School of Nanjing University and Nanjing Drum Tower Hospital Affiliated with Nanjing University Medical School, Nanjing University, Nanjing, China |
| Abstract: | |
| Keywords: | MVA pathway GGPPS VSMCs eicosanoids metabolism LTB4 LTE4 CYB5R3 eicosanoid inflammation vascular smooth muscle cells metabolism liposome cholesterol metabolism apoptosis antibody |