Effects of diurnal loading on the transport of charged antibiotics into intervertebral discs |
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| Affiliation: | 1. Dept. of Mechanical & Aerospace Engineering, University of Miami, Coral Gables, FL, USA;2. Dept. of Orthopaedics, University of Miami, Coral Gables, FL, USA;1. Tissue Biomechanics Lab, Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA;2. Department of Mechanical and Aerospace Engineering, University of Miami, P.O. Box 248294, Coral Gables, FL, 33124-0624, USA;1. University of Pennsylvania, Philadelphia, PA 19104, USA;2. University of Delaware, 150 Academy St, 161 Colburn Lab, Newark, DE 19716, USA;1. Department of Mechanical and Aerospace Engineering, Tissue Biomechanics Laboratory, University of Miami, Coral Gables, FL 33124-0624, United States;2. Department of Biomedical Engineering, Tissue Biomechanics Laboratory, University of Miami, Coral Gables, FL 33124-0624, United States;1. Department of Orthopedic Surgery, VU University Medical Center, Amsterdam, The Netherlands;2. Department of Orthopedic Surgery, Noord-West Ziekenhuizen, Alkmaar, The Netherlands;3. MOVE Research Institute Amsterdam, Amsterdam, The Netherlands;4. Amsterdam Movement Sciences Institute, Amsterdam, The Netherlands;5. Faculty of Behavioral and Movement Sciences, VU University, Amsterdam, The Netherlands;6. Dept. of Medical Biology, Academisch Medisch Centrum, Amsterdam, The Netherlands |
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| Abstract: | The objective of this study was to quantitatively analyze the effect of diurnal loading on the transport of various charged antibiotics into negatively charged human intervertebral disc (IVD). Transport of charged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from z = +2 (positively charged) to z = −2 (negatively charged). An uncharged antibiotic (z = 0) was used as a control. Cases with transient antibiotic concentration at disc boundaries [to mimic intravenous (IV) infusion] were simulated. Our results showed that diurnal compression increased the concentrations in the nucleus pulposus (NP) region, but degreased the concentrations in the annulus fibrosus (AF) region for all charged or non-charged drugs. The overall concentration (averaged over disc) increased with diurnal compression. The diurnal compression had more effects on negatively charged antibiotics than positively charged ones. For example, at day 5 with diurnal compression, the diurnal compression increased the concentration of negatively charged drug (z = −1) in NP by 18.3%, but only by 6.6% for positively charged one (z = +1). In AF, diurnal compression decreased the concentration by 13.2% for negatively charged drug (z = −1) versus 1.2% for positively charged one (z = +1). Note these percentages are the averaged values over day 5. This study provides quantitative information on understanding the mechanisms of charged drug transport in human IVDs. |
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| Keywords: | Intervertebral disc Charged antibiotics Diurnal compression Drug delivery Finite element method |
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