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New phosphate derivatives of betulin as anticancer agents: Synthesis,crystal structure,and molecular docking study
Institution:1. Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Organic Chemistry, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland;2. Polish Academy of Sciences, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Department of Experimental Oncology, 12 R.Weigla Str., 53-114 Wroc?aw, Poland;3. Rainbow Pharmacy, 25 Jana Matejki Str., 43-600 Jaworzno, Poland;4. University of Silesia, Institute of Physics, 1 75Pu?ku Piechoty Str., 41 500 Chorzów, Poland;5. Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Biopharmacy, 8 Jedno?ci Str., 41-200 Sosnowiec, Poland;6. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 Curie-Sklodowska Str., 41-819 Zabrze, Poland;1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China;2. Xiangya Hospital of Central South University, Changsha 410008, PR China;3. School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, PR China;1. Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier cedex 5, France;2. CiTCoM, CNRS, UMR 8038, Université Paris Descartes, Sorbonne Paris Cité, 4 av. de l''Observatoire, Paris, France;3. LCBPT, CNRS, UMR 8601, Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, 45 rue des Saints-Pères, 75006 Paris, France;1. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowska 34 St., 41-819 Zabrze, Poland;2. School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland, Department of Biopharmacy, Jedno?ci 8, Sosnowiec, Poland;3. European Institute of Membranes, UMR CNRS 5635, University of Montpellier, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France;4. School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland, Department of Organic Chemistry, Jagiellońska 4, Sosnowiec, Poland;5. Center for Translational Research and Molecular Biology of Cancer Maria Sklodowska-Curie Institute – Oncology Center, Gliwice Branch, Wybrze?e Armii Krajowej Street 15, 44-101, Gliwice, Poland;1. Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Organic Chemistry, 4 Jagiellońska Str., 41-200 Sosnowiec, Poland;2. Rainbow Pharmacy, 25 Jana Matejki Str., 43-600 Jaworzno, Poland;3. University of Silesia, Institute of Physics, Department of Solid State Physics, 4 Uniwersytecka Str., 40-007 Katowice, Poland;4. Silesian Center for Education and Interdisciplinary Research, University of Silesia, 41-500 Chorzów, 75 Pu?ku Piechoty 1, Poland;5. Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Department of Cell Biology, 8 Jedno?ci Str., 41-200 Sosnowiec, Poland;6. University of Silesia, Institute of Physics, Department of Physics of Crystals, 4 Uniwersytecka Str., 40-007 Katowice, Poland;1. Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany;2. Birken AG, Streiflingsweg 11, Niefern-Öschelbronn, Germany;3. Department of Biology, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
Abstract:
Keywords:Betulin  Phosphate  Crystal structure  Molecular docking  Anticancer
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