Control of the synthesis of long-chain fatty acids and triacetic acid in E. coli |
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| Authors: | D J Brock K Bloch |
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| Affiliation: | 1. College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang Road, Nanjing, Jiangsu 210095, China;2. Institute of Agro-Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210095, China;1. School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea;2. School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea |
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| Abstract: | The soluble fatty acid synthetase from E. coli produces both saturated and unsaturated long-chain fatty acids from malonyl CoA and acetyl CoA in a process dependent on TPNH and ACP (Lennarz, Light and Bloch, 1962;Goldman and Vagelos, 1962). We have now observed that under certain conditions the synthesis of long-chain acids is suppressed and almost entirely replaced by the production of triacetic acid (TAA, 3, 5-diketohexanoic acid). This communication describes the isolation and characterization of TAA as its lactone (TAL), and details the conditions under which it is formed at the expense of long-chain acids. |
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