Novel selective biocatalytic deacylation studies on key precursors for bicyclonucleosides |
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| Authors: | Prasad Ashok K Singh Sunil K Kalra Neerja Singhal Nidhi Wengel Jesper Parmar Virinder S |
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| Institution: | Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, India. ashokenzyme@yahoo.com |
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| Abstract: | Immobilized Candida antarctica lipase and Thermomyces lanuginosus lipase catalyze the deacylation of precursors of LNA analogs, 4'-C-acyloxymethyl-2',3',5'-tri-O-acyl-beta-L-threo-pentofuranosylthymine and 4-C-acyloxymethyl-3,5-di-O-acyl-1,2-O-(1-methylethylidene)-beta-L-threo-pentofuranose, respectively in a highly selective and efficient manner. |
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