Monoaminergic neurons of the mudpuppy retina |
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Authors: | Alan Adolph John E Dowling Dr Berndt Ehinger |
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Institution: | (1) The Eye Institute of Retina Foundation, The Biological Laboratories, Harvard University, Cambridge, Mass., USA;(2) Department of Ophthalmology, University of Lund, Lund, Sweden;(3) Department of Ophthalmology, Lasarettet i Lund, S-221 85 Lund, Sweden |
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Abstract: | Summary The mudpuppy retina was investigated with the histofluorescence method of Falck and Hillarp in normal animals and in animals injected intraocularly with -methylnoradrenaline, 5,6-dihydroxytryptamine, or a combination of the two drugs. Catecholaminergic amacrine cells were found to form a thin layer of terminals at the border between the inner nuclear and the inner plexiform layers. Catecholaminergic interplexiform cells were not found. Indoleamine-accumulating amacrine cells were also observed. They are fifteen to twenty times more numerous than the catecholaminergic cells, and their terminals occur diffusely throughout the inner plexiform layer. In a number of eyes the majority of the indoleamine-accumulating terminals were eliminated with intraocular injections of the neurotoxin, 5,7-dihydroxytryptamine, but the reproducibility of this effect was not consistent. Intravitreal injections of 5,6-dihydroxytryptamine were used to label both types of neurons for electron microscopy. They were found to make conventional type synapses on amacrine cells and, less frequently, on bipolar cells. |
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Keywords: | Monoaminergic neurons Retina Amacrine cells Neurotoxins Mudpuppy Necturus maculosus Neurotransmitters Electron microscopy |
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