Cobalamin inactivation induces formyltetrahydrofolate synthetase |
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| Authors: | R Deacon J Perry M Lumb I Chanarin |
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| Affiliation: | MRC Clinical Research Centre, Northwick Park Hospital, Harrow, UK. |
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| Abstract: | Loss of cobalamin function produces profound changes in the metabolism of formate. There is impaired synthesis of formyltetrahydropteroylglutamate synthetase (CHO-H4PteGlu), accumulation of endogenous formate and impaired utilization of [14C]formate. There are contradictory reports on the effect of cobalamin inactivation on CHO-H4PteGlu synthetase. This study confirms a significant increase in synthetase activity following cobalamin inactivation. |
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