Phosphatidylcholine synthesis in platelets is stimulated by diacylglycerol but not by phorbol ester |
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| Authors: | J G Muir A W Murray |
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| Affiliation: | School of Biological Sciences, Flinders University, Bedford Park, South Australia. |
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| Abstract: | The biosynthesis of phosphatidylcholine (PC) in platelets was followed by measuring the incorporation of 32Pi. Incorporation into PC was stimulated by treatment with Clostridium perfringens phospholipase C or with the synthetic diacylglycerol sn-1,2-dioctanoylglycerol. However, neither the phorbol ester tumour promoter 12-O-tetradecanoylphorbol-13-acetate or thrombin stimulated 32Pi incorporation into PC. We conclude that phorbol ester does not stimulate the hydrolysis of PC to diacylglycerol in platelets. |
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