The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans |
| |
Authors: | Puri Satish Chandra Nazir Asiya Chawla Raman Arora Rajesh Riyaz-Ul-Hasan S Amna Touseef Ahmed Bilal Verma Vijeshwar Singh Shikha Sagar Ravinder Sharma Ashok Kumar Raj Sharma Rakesh Kumar Qazi Ghulam Nabi |
| |
Institution: | Natural Products Chemistry Division, Regional Research Laboratory (CSIR), Jammu 180001, India. rks@inmas.org |
| |
Abstract: | The aryl tetralin lignans are synthesized by Podophyllum sps. and are in great demand worldwide due to their use in synthesis of topoisomerase inhibitors. However, the sustained production of these aryl tetralin lignans requires large-scale harvesting from the natural environments, which has resulted in the plant-endangered status. In view of the difficulties in their total chemical synthesis, cultivation and failure of metabolic engineering approaches, there is a need to search for alternative sources of production of aryl tetralin lignans. We unequivocally established the methodology for isolation, identification, and characterization of a novel fungal endophyte (Trametes hirsuta) that produces aryl tetralin lignans consistently as shown by HPLC, LC-MS, LC/MS-MS and (1)H NMR. The lignans produced by the microorganism are biologically active, and exhibit potent antioxidant, anticancer and radioprotective properties. This strategy promises to improve the production of these therapeutically important compounds at lower costs. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|