Antibodies to Anopheles midgut reduce vector competence for Plasmodium vivax malaria |
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Authors: | K. ALAGARATNAM SRIKRISHNARAJ RANJAN RAMASAMY MANTHRI S. RAMASAMY |
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Affiliation: | Vector Biology, Institute of Fundamental Studies, Kandy, Sri Lanka;*Malaria Laboratories, Institute of Fundamental Studies, Kandy, Sri Lanka |
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Abstract: | Anopheles tessellatus mosquitoes ingested Plasmodium vivax gametocytes in human erythrocytes suspended in rabbit sera with and without anti-mosquito midgut antibodies. When the mosquito bloodmeal contained anti-midgut antibodies, fewer oocysts of P. vivax developed on the mosquito midgut and the proportion of mosquitoes becoming infected was significantly reduced. Complement inactivated serum also reduced the infection rate and load. A second bloodmeal containing anti-midgut antibodies, given 48 or 72 h later, did not enhance the transmission-blocking effect. IgG purified from antimidgut sera was shown to mediate the transmission-blocking effect. |
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Keywords: | Anopheles tessellatus Plasmodium vivax anti-mosquito antibodies malaria mosquito midgut transmission blocking immunity. |
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