Directed synthesis of 2',5'-oligoadenylates with increased stability towards phosphodiesterases |
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Authors: | A V Itkes M Ia Karpe?ski? O N Kartasheva S N Mikha?lov G P Moiseev |
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Abstract: | Phosphodiesterase stability of synthetic analogs of 2',5'-oligoadenylates, the mediators of antiviral and antiproliferative action of interferons was analysed. The analogs with a 3'-terminal acyclic nucleoside residue were prepared. These analogs were treated with NIH3T3 cell lysate, mice liver homogenate and snake venom phosphodiesterase. All analogs have demonstrated a high stability as compared with the natural 2',5'-oligoadenylate and its 3'-deoxyderivative. The possible biological activity of these stable analogs of 2',5'-oligoadenylates is discussed. |
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