An in vitro study of long-term potentiation in the carp (Cyprinus carpio L.) olfactory bulb |
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Authors: | M Satou R Hoshikawa Y Sato K Okawa |
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Institution: | (1) Division of Information Science, Graduate School of Integrated Science, Yokohama City University, 236-0027 Yokohama, Japan |
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Abstract: | Long-term potentiation (LTP) of synaptic transmission is considered a cellular mechanism for neural plasticity and memory
formation. Previously, we showed that in the carp olfactory bulb, LTP occurs at the dendrodendritic mitral-to-granule cell
synapse following tetanic electrical stimulation applied to the olfactory tract, and suggested that it is involved in the
process of olfactory memory formation. As a first step towards understanding mechanisms underlying plasticity at this synapse,
we examined the effects of various drugs (glutamate and GABA receptor agonists and antagonists, noradrenaline, and drugs affecting
cAMP signaling) on dendrodendritic mitral-to-granule cell synaptic transmission in an in vitro preparation. Two forms of LTP
are involved: a postsynaptic form (tetanus-evoked LTP) and a presynaptic form. The postsynaptic form is evoked at the granule
cell dendrite following tetanic olfactory tract stimulation and is suppressed by the NMDA receptor antagonist, D-AP5, enhanced
by noradrenaline, and occluded by the metabotropic glutamate receptor agonist, trans-ACPD. The presynaptic form occurs at the mitral cell dendrite following blockade of the GABAA receptor by picrotoxin and bicuculline, or via activation of cAMP signaling by forskolin and 8-Br-cAMP. |
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Keywords: | Long-term potentiation Dendrodendritic mitral-to-granule cell synapse Olfactory bulb Carp In vitro preparation |
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