阿莫西林克拉维酸钾联合阿奇霉素治疗社区获得性肺炎的临床疗效研究

目的：探讨阿莫西林克拉维酸钾联合阿奇霉素治疗社区获得性肺炎（CAP）的临床疗效。方法：选取于2010年1月-2012年1月收治的CAP患者145例，采用随机数字表法将其分为两组，其中治疗组73例，对照组72例。治疗纽给予阿莫西林克拉维酸钾联合阿奇霉素治疗，对照组只单纯给予应用阿莫西林克拉维酸钾。两组疗程均为7～14d。于治疗后比较两组的临床疗效。结果：（1）治疗组治愈、显效、有效、无效分别为43例（58．9％）、16例（21．9％）、8例（11．0％）、6例（8．2％）；对照组分别为20例（27．8％）、26例（36．1％）、14例（19．4％）、12例（16．7％）。两组疗效比较，差异有统计学意义（P〈0．05）。（2）治疗组胃肠道反应、静脉滴注局部疼痛、皮疹的发生分别为6例（8．2％）、7例（9．6％）、3例（4．1％），总不良反应发生率为16例（21．9％）；对照组分别为5例（6．9％）、6例（8.3％）、3例（4．2％）、14例（19．4％）。两组不良反应发生率比较，差异无统计学意义（P〉0．05）。结论：阿莫西林克拉维酸钾联合阿奇霉素治疗CAP疗效好。

Amoxicillin Clavulanic Potassium Combined with Azithromycin Treatment on Community-Acquired Pneumonia

Objective： Our study focused on the clinical efficacy of amoxicillin clavulanic potassium acid combined with azithromycin for the treatment of community-acquired pneumonia （CAP）. Methods： 145 CAP patients who were admittied during January, 2010 -January 2012 were selected The patients were divided into two groups using a random number table, including treatment group （73 cases） and control group （72 cases）, The treatment group received amoxicillin clavulanic potassium acid and azithromycin treatment, control group was applicated only by amoxicillin clavulanic potassium acid. Both groups were treated for 7 - 14 days. The clinical efficacy were compared after treatment. Results： （1） In the treatment group, the amounts of cured, effective and invalid patients were 43 cases （58.9%）, 16 cases （21.9%）, 8 cases （11.0%）, 6 cases （8.2%） respectively, and they were 20 cases （27.8 %）, 26 cases （36.1%）, 14 cases （19.4%）, 12 cases （16.7%） in the control group. The difference between the two groups was statistically significant （P 〈0.05）. （2） In the treatment group, gastrointestinal reactions, local pain induced by intravenous infusion, and rash occurred in 6 cases （8.2%）, 7 cases （9.6%） and 3 cases （4.1%）, the total adverse reaction rate was 21.9%（16 cases）. However, in the control group they were five cases （6.9%）, 6 cases （8.3%）, 3 cases （4.2%）, 14 cases （19.4%）. The adverse reaction rates were not statistically significant between two groops（P〉0.05）. Conclusion： Amoxicillin clavulanic potassium combined with azithromycin treatment has better curative efficacy to CAP.