The lack of genotoxicity of sodium fluoride in a battery of cellular tests |
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| Authors: | Charles C. Tong Charlene A. McQueen Sharma Ved Brats Gary M. Williams |
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| Affiliation: | (1) American Health Foundation, Valhalla, New York;(2) American Health Foundation, 1 Dana Rd., 10595 Valhalla, NY;(3) Present address: Biological Services Division, United States Testing Company, Inc., 1415 Park Avenue, 07030 Hoboken, NJ;(4) Present address: Braton Biotech, Inc., 1 Taft Court, 20850 Rockville, MD |
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| Abstract: | In a comprehensive assessment of genotoxicity, sodium fluoride was evaluated in a battery of cellular tests providing different genetic end points and biotransformation capabilities. The tests included the following: rat hepatocyte primary culture/DNA repair assay, Salmonella typhimurium histidine locus reversion assay, adult rat liver epithelial cell/hypoxanthine guanine phosphoribosyl transferase mutation assay, and sister chromatid exchange in two target cell types, human peripheral blood lymphocytes and Chinese hamster ovary cells. Negative findings were made in all assays, indicating that sodium fluoride is not genotoxic in these assays.Abbreviations ARL adult rat liver epithelial cell - CHO Chinese hamster ovary cell - HGPRT hypoxanthineguanine phosphoribosyl transferase - HPBL human peripheral blood lymphocyte - HPC hepatocyte primary culture - SCE sister chromatid exchange |
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| Keywords: | in vitro test battery non-genotoxic sodium fluoride |
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