|
|||||
|
|
Desensitization of the D-2 dopamine receptor and the β2-adrenoceptor in the intermediate lobe of the rat pituitary gland |
|
| Authors: | K. Miyazaki J.M. Saavedra T.E. Cote J.W. Kebabian |
| Affiliation: | a Experimental Therapeutics Branch, NINCDS, National Institutes of Health, Bethesda, MD 20205, U.S.A. b Laboratory of Clinical Sciences, NIMH, National Institutes of Health, Bethesda, MD 20205, U.S.A. |
| Abstract: | A D-2 dopamine receptor and a β2-adrenoceptor occur in the intermediate lobe of the rat pituitary gland (IL). Exposure of intact IL tissue to a D-2 agonist diminished the ability of dopaminergic agonists [but not 5′-guanylyl imidodiphosphate (Gpp(NH)p)] to inhibit adenylate cyclase activity. Conversely, exposure of intact IL tissue to a β-adrenergic agonist diminished the ability of a β-adrenergic agonist (but not forskolin) to stimulate adenylate cyclase activity. Treatment of ovariectomized rats with 17β-estradiol desensitizes the β2-adrenoceptor but not the D-2 receptor. Desensitization of the IL catecholamine receptors is discussed within the framework of a previously published “working model” of these receptors. |
| Keywords: | Address correspondence to: J. W. Kebabian Building 10 Room 5C-110 NIH Bethesda MD 20205 U.S.A. |
| 本文献已被 ScienceDirect 等数据库收录！ | |