The sodium "leak" has finally been plugged |
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Authors: | Snutch Terrance P Monteil Arnaud |
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Affiliation: | Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4. snutch@msl.ubc.ca |
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Abstract: | Most electrophysiologists generally do not speak highly of leak currents. In reality, these conductances represent a crucial functional mechanism by which neurons control resting membrane potentials. A new study in Cell by Lu et al. has surprisingly confirmed the identity of the long-sought voltage-insensitive sodium leak conductance to be encoded by the third branch of the voltage-gated sodium and calcium channel family. |
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