4-Aminopyrimidines as novel HIV-1 inhibitors |
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Authors: | Gadhachanda Venkat R Wu Baogen Wang Zhiwei Kuhen Kelli L Caldwell Jeremy Zondler Helmut Walter Harald Havenhand Mark He Yun |
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Affiliation: | Genomics Institute of the Novartis Research Foundation (GNF), 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA. |
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Abstract: | A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets. |
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