Cell division and sister chromatid exchanges in 45,X/46,X,i(Xq) mosaicism |
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Authors: | Kyra Michalová Jana Málková Josef Urban |
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Affiliation: | (1) Third Medical Department, Charles University, U nemocnice 1, 12821 Prague 2, CSSR;(2) Institute of Social Medicine, Prague, CSSR;(3) Organization of Health Services, Prague, CSSR |
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Abstract: | Summary The kinetics of cell division and sister chromatid exchanges were studied in PHA-stimulated short-term cultivations of peripheral blood by means of the BUDR/FPG technique in controls and in five patients with 45,X/46,X,i(Xq) mosaicism. No significant differences in the length of the cell cycle were observed between 45,X/46,X,i(Xq) and control 46,XX cells. The number of SCE on late i(Xq) was only nonsignificantly elevated (0.6 per i(Xq)) against the value expected on the basis of its relative length. |
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