Clinical Evaluation of the Bioavailability of Zinc-enriched Yeast and Zinc Gluconate in Healthy Volunteers |
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Authors: | Thomas A Tompkins Nadine E Renard Akira Kiuchi |
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Institution: | (1) Institut Rosell-Lallemand Inc., 6100 Avenue Royalmount, Montreal, Quebec, Canada, H4P 2R2;(2) Institut Rosell Inc., 8480 Boulevard Saint Laurent, Montreal, Quebec, Canada, H2P 2M6;(3) Miwa Seiyaku Co., Ltd., 1-1-10 Tabatashinmachi, Kita-ku, Tokyo 114-0012, Japan |
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Abstract: | Zinc (Zn)-enriched yeast and gluconate are considered two of the more biologically available supplements. However, there have
been few reports comparing the bioavailability of these supplements. The objective of this study was to demonstrate whether
Zn was absorbed better by healthy male volunteers when given supplements where the mineral is found organically bound in yeast
or as a salt gluconate form. The trial used a randomized, two-way crossover design. Urine, blood, and fecal samples were collected
and analyzed over a 48-h period after a single dose of supplement. The net Zn balance and the relative bioavailability were
calculated. No differences were observed in urine excretion of the two supplements. Zinc gluconate gave higher Zn concentrations
in the blood in the first 6 h but also showed greater losses in the feces. Zinc yeast also increased in blood with time but
showed significantly less loss in the feces. Thus, the net Zn balance after 48 h for Zn yeast was 9.46 but for Zn gluconate
it was −2.00, indicating that Zn gluconate supplementation contributed to a net loss of Zn. It was concluded that organic
Zn yeast supplements are more biologically available than Zn gluconate salts. |
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Keywords: | Zinc gluconate Zinc-enriched yeast Bioavailability Zinc absorption |
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