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Human ES cell profiling broadens the reach of bivalent domains
Authors:Sharov Alexei A  Ko Minoru S H
Affiliation:Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, Baltimore, MD 21224, USA.
Abstract:In this issue of Cell Stem Cell, Pan et al. (2007) and Zhao et al. (2007) report genome-wide histone H3 trimethylations at lysines 4 and 27 in human embryonic stem (ES) cells. Similar gene sets arise via different experimental systems, advancing our understanding of stem cell epigenetics.
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