Molecular cloning and sequence analysis of a chicken ornithine decarboxylase cDNA |
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Authors: | R JOHNSON G BULFIELD |
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Institution: | AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, UK. |
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Abstract: | A chicken embryo cDNA library was screened with a mouse probe for ornithine decarboxylase (ODC) and 14 positively hybridizing clones isolated. The longest of these (1.7 kb) was sub-cloned and sequenced. It is estimated that the clone comprises approximately 98% of the coding region for chicken ODC. The DNA sequence shows 78% identity with the human ODC cDNA sequence and the deduced amino acid sequence is almost 90% homologous to mouse and human. Both the peptide and cDNA sequences show interesting potential regulatory features which are discussed here. |
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Keywords: | chicken growth ornithine decarboxylase sequence |
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