Synthesis of probes for the active site of leucine dehydrogenase. |
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| Authors: | A Sutherland C L Willis |
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| Affiliation: | School of Chemistry, University of Bristol, Cantock's Close, UK. |
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| Abstract: | A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination. |
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