Antibacterial substances of low molecular weight isolated from the blowfly, Lucilia sericata |
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Authors: | Huberman L Gollop N Mumcuoglu K Y Breuer E Bhusare S R Shai Y Galun R |
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Affiliation: | Department of Food Sciences, Volcani Center, ARO, Beit Dagan, Israel. |
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Abstract: | Low molecular weight compounds were isolated by high-performance liquid chromatography from the maggot or haemolymph extracts of Lucilia sericata (Meigen) (Diptera: Calliphoridae). Using gas chromatography-mass spectrometry analysis, three compounds were obtained: p-hydroxybenzoic acid (molecular weight 138 Da), p-hydroxyphenylacetic acid (molecular weight 152 Da) and octahydro-dipyrrolo[1,2-a;1',2'-d] pyrazine-5,10-dione (molecular weight 194 Da), also known as the cyclic dimer of proline (or proline diketopiperazine or cyclo[Pro,Pro]). All three molecules revealed antibacterial activity when tested against Micrococcus luteus and/or Pseudomonas aeruginosa, and the effect was even more pronounced when these molecules were tested in combination and caused lysis of these bacteria. |
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Keywords: | Lucilia sericata Micrococcus luteus Pseudomonas aeruginosa antibacterial cyclo(Pro,Pro) p-hydroxybenzoic acid p-hydroxyphenylacetic acid |
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