Metabolism of halophilic archaea |
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Authors: | Michaela Falb Kerstin Müller Lisa Königsmaier Tanja Oberwinkler Patrick Horn Susanne von Gronau Orland Gonzalez Friedhelm Pfeiffer Erich Bornberg-Bauer Dieter Oesterhelt |
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Affiliation: | Department of Membrane Biochemistry, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. |
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Abstract: | In spite of their common hypersaline environment, halophilic archaea are surprisingly different in their nutritional demands and metabolic pathways. The metabolic diversity of halophilic archaea was investigated at the genomic level through systematic metabolic reconstruction and comparative analysis of four completely sequenced species: Halobacterium salinarum, Haloarcula marismortui, Haloquadratum walsbyi, and the haloalkaliphile Natronomonas pharaonis. The comparative study reveals different sets of enzyme genes amongst halophilic archaea, e.g. in glycerol degradation, pentose metabolism, and folate synthesis. The carefully assessed metabolic data represent a reliable resource for future system biology approaches as it also links to current experimental data on (halo)archaea from the literature. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | Metabolism Archaea Haloarchaea Halobacterium salinarum Pathway database Metabolic pathways Enzymes Comparative genomics |
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