Synthesis of 1-(2-hydroxy-3-methoxypropyl)uracils and their activity against L1210 and macrophage raw 264.7 cells |
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| Authors: | Copik Alicja Suwinski Jerzy Walczak Krzysztof Bronikowska Joanna Czuba Zenon Król Wojciech |
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| Institution: | Institute of Organic Chemistry and Technology, Silesian University of Technology, Krzywoustego, Poland. |
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| Abstract: | The title compounds were obtained from appropriate 5-substituted uracil derivatives and 1,2-oxy-3-methoxypropane in the presence of sodium hydride. Under similar conditions 5-iodouracil gave 2-methoxymethyl-2,3-dihydro-oxazolo3,2-c]pyrimidine-5,7-dione as a result of intramolecular cine type nucleophilic substitution. Cytotoxicity of 1-(2-hydroxy-3-methoxypropyl)-5-substituted uracil derivatives against L1210 and macrophage RAW 264.7 cells in vitro was examined. |
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