Synthesis and characterization of nucleoside derivatives,n-(benzoyl)-n-(deoxyguanosin-8-yl)4-aminobiphenyl and n-(2'-deoxyguanosin-8-yl)4-aminobiphenyl via alpha-phenyl-n-(4-biphenyl)nitrone |
| |
| Authors: | Mallesha H Kumar K R Ravi Rangappa K S |
| |
| Institution: | Department of Studies in Chemistry, University of Mysore, Manasagangotri, India. |
| |
| Abstract: | Lead tetraacetate (LTA) oxidation of alpha-Phenyl-N-(4-bipheny])nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2'-deoxyguanosin-8-yl)-4-aminobiphenyl (11). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
