Tumor antigens: Biological activity of components of soluble antigens of MTV-induced mammary tumors |
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| Authors: | Calbert A. Laing Gloria H. Heppner J. George Bekesi |
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| Affiliation: | (1) Department of Neoplastic Diseases, Mount Sinai School of Medicine, 100th Street & Fifth Avenue, 10029 New York, N.Y.;(2) Roger Williams General Hospital, 02908 Providence, R.I., USA;(3) Present address: Howard University College of Medicine, 200589 Washington, D.C. |
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| Abstract: | Summary Antigens (AMMT) of MTV-induced mammary tumors of BALB/cfC3H CRGL mice were solubilized by treatment of homogenates of the tumor with 1 M perchloric acid. The soluble antigens exhibited biological activity by their ability to induce DNA synthesis in spleen cells of mice bearing syngeneic transplants of the tumor. AMMT-induced DNA synthesis, however, was abrogated by serum from tumor-bearing mice. AMMT neutralized complement-dependent rabbit anti-ML(r) antibody activity and intracytoplasmic fixed cell immunofluorescent activity of the same antibodies. One component of AMMT has an electrophoretic mobility pattern identical to that of ML(r) antigen. Thus, AMMT may share antigenicity with MTV-specific antigens. |
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