Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom. |
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| Authors: | R Conde F Z Zamudio B Becerril L D Possani |
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| Institution: | Department of Molecular Recognition and Structural Biology, Biotechnology Institute, National Autonomous University of Mexico, Avenida Universidad, 2001, Apartado Postal 510-3, Cuernavaca, Mexico. |
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| Abstract: | The primary structure of a phospholipase A2, with unique structural and functional characteristics, was determined. The large subunit has 108 amino acid residues, linked by a disulfide bridge to the small subunit, which contains 17 residues. Its gene was cloned from a cDNA library. The nucleotide sequence showed that the same RNA messenger encodes both subunits, separated only by a pentapeptide, that is processed during maturation. |
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