Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis |
| |
Authors: | Mauro Degli Esposti Holly McLennan |
| |
Institution: | Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton 3168, Victoria, Australia |
| |
Abstract: | Observations of apoptosis in virtual anaerobiosis have raised doubts on the significance of reactive oxygen species in the cascade of events of programmed cell death. This work presents evidence that cells and mitochondrial preparations produce similar levels of hydrogen peroxide under either aerobic or virtually anaerobic conditions. These levels are relevant to the increased production of radicals induced by a ceramide analog that promotes apoptosis. This ceramide acts at center o of mitochondrial complex III. |
| |
Keywords: | Reactive oxygen species Mitochondrion Apoptosis Ceramide |
本文献已被 ScienceDirect 等数据库收录! |