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Stimulation of protective and cross-protective immunity against influenza B virus after adjuvant mucosal immunization of mice |
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| Authors: | L. Prokešová P. Zanvit M. Havlíčková J. Táčner M. Jirkovská P. Petrásková O. Novotná D. Čechová J. Julák |
| Affiliation: | 1.Institute of Immunology and Microbiology, 1st Faculty of Medicine,Charles University in Prague,Prague,Czech Republic;2.National Institute of Public Health,Prague,Czech Republic;3.Institute of Histology and Embryology, 1st Faculty of Medicine,Charles University in Prague,Prague,Czech Republic |
| Abstract: | Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even against phylogenetically distant virus drift variant B/Lee/40 lethal for mice. |
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