Effect of lactoperoxidase on the antimicrobial effectiveness of the thiocyanate hydrogen peroxide combination in a quantitative suspension test |
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| Authors: | A Welk Ch Meller R Schubert Ch Schwahn A Kramer H Below |
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| Affiliation: | (1) Department of Restorative Dentistry, Periodontology and Endodontology, Dental School, University of Greifswald, Greifswald, Germany;(2) Department of Operative Dentistry and Periodontology, Center of Dentistry, Oral Medicine, and Maxillofacial Surgery, University Hospital Tuebingen, Tuebingen, Germany;(3) Private dental practice, Berlin, Germany;(4) Institute of Hygiene and Environmental Medicine, University of Greifswald, Greifswald, Germany |
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| Abstract: | Background The positive antimicrobial effects of increasing concentrations of thiocyanate (SCN-) and H2O2 on the human peroxidase defence system are well known. However, little is known about the quantitative efficacy of the human peroxidase thiocyanate H2O2 system regarding Streptococcus mutans and sanguinis, as well as Candida albicans. The aim of this study was to evaluate the effect of the enzyme lactoperoxidase on the bactericidal and fungicidal effectiveness of a thiocyanate-H2O2 combination above the physiological saliva level. To evaluate the optimal effectiveness curve, the exposure times were restricted to 1, 3, 5, and 15 min. |
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