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Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife

Authors:	Gabriele?Neu-Yilik author-information" > author-information__contact u-icon-before" > mailto:gaby.neu-yilik@med.uni-heidelberg.de" title=" gaby.neu-yilik@med.uni-heidelberg.de" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Niels?H?Gehring,Matthias?W?Hentze,Andreas?E?Kulozik

Affiliation:	(1) Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany;(2) Molecular Medicine Partnership Unit, EMBL/University of Heidelberg, Im Neuenheimer Feld 156, 69120 Heidelberg, Germany;(3) EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany

Abstract:	Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.

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