EFFECTS OF ETHANOL ON SEROTONIN METABOLISM IN BRAIN

The effect of ethanol on serotonin metabolism in brains of mice was determined both after a single injection and ‘chronic’ administration of ethanol. Behavioral effects were also monitored.‘Chronic’ administration of ethanol by inhalation to mice resulted in an increased susceptibility to Metrazole induced seizures. This susceptibility was evident for 48 h after ‘withdrawal’ of mice from ethanol chambers. No differences in brain 5-HT levels between control and ethanol treated mice were evident during withdrawal. However, a significant elevation in brain 5-HIAA levels was noted during this period. Short lived increases in brain 5-HIAA levels were also noted after a single injection of ethanol. Ethanol treatment produced no significant changes in the activity of brain MAO, aldehyde dehydrogenase, or aldehyde reductase. Other mechanisms for ethanol induced increases in brain 5-HIAA are discussed.