丹酚酸B对高糖日粮小鼠消化系统自由基水平的影响

本文研究了丹酚酸B(salvianolic acid B,Sal B)对灌注及长期摄食高糖小鼠活性氧自由基(reactive oxygen species,ROS)的影响.结果表明:灌胃高糖使小鼠全血ROS于1.5 h达到最大值,灌胃葡萄糖的ROS释放量显著高于蔗糖(P＜0.05);灌胃高糖使小鼠血糖浓度于0.5 h达到最高,灌胃葡萄糖的小鼠血糖浓度有高于灌胃蔗糖的小鼠血糖浓度的趋势(P＞0.05);添加Sal B后并没有改变灌胃高糖小鼠的全血ROS释放和血糖浓度变化趋势,但有降低血糖趋势(P＞0.05),显著减少了ROS的释放量(P＜0.05);添加Sal B后显著降低长期高糖膳食小鼠的全血、肝脏、胰腺、胃、十二指肠、空肠和回肠的ROS释放量.

Effect of Salvianolic Acid B on Digestive System ROS Level in High Sugar Dietary Mice

This research is to study the effect of salvianolic acid B(Sal B)on the reactive oxygen species(ROS)level in intragastric(ig)glucose mice and chronic ingestion of high sugar dietary mice.Forty Kunming mice were stochastic divided into 4 groups with different treatments to determine the levels of blood sugar and ROS.Another 3 groups of ten Kunming mice were prepared to determine the levels of ROS in blood,liver,pancreas,stomach,duodenum,jejunum and ileum.The results showed that the high sugar ig result in the highest level of ROS in the blood at 1.5 h,and the level of ROS in the glucose ig mice was significantly higher than that in the sucrose ig mice(P＜0.05);High sugar ig led the blood glucose highest at 0.5 h,and the blood sugar of glucose ig mice showed a higher tendency than the sucrose ig mice (P＞0.05);Sal B did not change the trend of blood sugar and ROS in high sugar ig mice,but lowered the blood sugar(P＞0.05)and significantly reduced the ROS level(P＜0.05);Sal B could significantly lower the level of ROS in blood,liver,pancreas,stomach,duodenum,jejunum and ileum of the mice which was secularly ingested high sugar dietary.