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Development and scale‐up of the recovery and purification of a domain antibody Fc fusion protein‐comparison of a two and three‐step approach |
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| Authors: | Sibylle Herzer Atul Bhangale Gregory Barker Isha Chowdhary Matthew Conover Brian W. O'Mara Lily Tsang Shi‐Yu Wang Stanley R. Krystek Jr Yan Yao Siegfried Rieble |
| Affiliation: | 1. 908‐388‐6354;2. Biologics Development, BLY‐106G, Bristol‐Myers Squibb, 519 Route 173 West, Bloomsbury, New Jersey;3. Biologics Development, BMS, Bloomsbury, New Jersey;4. Biologics Development, BMS, Seattle, Washington;5. Gilead Sciences, Oceanside, California;6. CADD, BMS, Lawrenceville, New Jersey |
| Abstract: | |
| Keywords: | caprylate purification Fc‐fusion protein process development design of experiments scale‐up |