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Integrated cell and process engineering for improved transient production of a “difficult‐to‐express“ fusion protein by CHO cells |
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| Authors: | Yusuf B Johari Scott D Estes Christina S Alves Marty S Sinacore David C James |
| Institution: | 1. Department of Chemical and Biological Engineering, University of Sheffield, ChELSI Institute, Mappin Street, Sheffield, UK;2. Cell Culture Development, Biogen Idec, Inc., Cambridge, Massachusetts;3. +44‐114‐222‐7505+44‐114‐222‐7501 |
| Abstract: | |
| Keywords: | Chinese hamster ovary cells difficult‐to‐express proteins aggregation unfolded protein response cell engineering chemical chaperones |