|
|||||
|
|
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human |
|
| Authors: | Nicolas Gillet Arnaud Florins Mathieu Boxus Catherine Burteau Annamaria Nigro Fabian Vandermeers Hervé Balon Amel-Baya Bouzar Julien Defoiche Arsène Burny Michal Reichert Richard Kettmann Luc Willems |
| Affiliation: | 1. Molecular and Cellular Biology, Faculté Universitaire des Sciences Agronomiques, Gembloux, Belgium 2. National Veterinary Research Institute, Pulawy, Poland 3. Molecular and Cellular Biology laboratory, Luc Willems, National fund for Scientific Research, 13 avenue Maréchal Juin, 5030, Gembloux, Belgium |
| Abstract: | In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |