| 高效液相法测定盐酸乐卡地平片含量 |
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| 引用本文： | 李竹英,刘胜姿,陆艳艳,邱细敏,蒋诚,李威. 高效液相法测定盐酸乐卡地平片含量[J]. 激光生物学报, 2011, 20(5): 695-698. DOI: 10.3969/j.issn.1007-7146.2011.05.023 |
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| 作者姓名： | 李竹英 刘胜姿 陆艳艳 邱细敏 蒋诚 李威 |
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| 作者单位： | 1. 郴州市妇幼保健院,湖南郴州,423000
2. 湖南师范大学医学院药学系,湖南长沙,410006 |
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| 基金项目： | 湖南省教育厅重点项目(10A071) |
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| 摘 要： | 使用高效液相色谱法测定乐卡地平片含量,流动相为乙腈-0.O1 mol/L乙酸铵溶液—三乙胺(650:350:1)(pH 6.0).结果显示盐酸乐卡地平在浓度为2.05～404.0μg/mL范围内具有良好的线性关系,盐酸乐卡地平片剂的平均标示量含量为100.3％,符合要求.研究表明HPLC色谱法对乐卡地平片剂进行含量测定...
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| 关 键 词： | 高效液相法(HPLC) 盐酸乐卡地平片 含量测定 |
Determination of the Content of Lercanidipine Hydrochloride by HPLC |
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| LI Zhuying,LIU Shengzi,LU Yanyan,QIU Ximin,JIANG Cheng,LI Wei. Determination of the Content of Lercanidipine Hydrochloride by HPLC[J]. ACTA Laser Biology Sinica, 2011, 20(5): 695-698. DOI: 10.3969/j.issn.1007-7146.2011.05.023 |
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| Authors: | LI Zhuying LIU Shengzi LU Yanyan QIU Ximin JIANG Cheng LI Wei |
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| Affiliation: | LI Zhuying~1,LIU Shengzi~(2*),LU Yanyan~2,QIU Ximin~2,JIANG Cheng~2,LI Wei~2 (1.Maternity and Child Care Centers of Chenzhou City,Chenzhou 423000,Hunan,China,2.Pharmacy Department of Medical College of Hunan Normal University,Changsha 410006,China) |
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| Abstract: | Determine the content of Lercanidipine Hydrochloride with high-performance liquid chromatography （HPLC）. Use HPLC, mobile phase ： acetonitrile-0.01 mol/L ammonium acetate solution - Triethylamine （ 650：35 ： 1 ） （pH 6. 0 ）. Lercanidipine Hydrochloric has good linear relationship in the scope of the concentration of 2. 05 404.0 μg/mL. The average contents of Lercanidipine Hydrochloric was 100.3% , which was in accordance with pharmacopoeial requirements. HPLC was used to determine the content of Lercanidipine Hydrochloric tablet, which has good linearity, stability, and precision, high efficiency. It can be used for the determination of Lercanidipine Hydrochloric. |
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| Keywords: | HPLC Le rcanidipine Hydrochloric content determination |
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