An elderly diabetic case of ochronosis with depression and chronic pain |
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Authors: | Naharci Mehmet Ilkin Ak Mehmet Bozoglu Ergun Karadurmus Nuri Isik Ahmet Turan Doruk Huseyin |
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Affiliation: | Gulhane School of Medicine, Department of Internal Medicine, Ankara, Turkey. |
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Abstract: | Alkaptonuria (ochronosis) is a rare autosomal recessive disorder featuring a genetic error in the amino acid metabolism. A defect in the tyrosine metabolism results in the accumulation and deposition of homogentisic acid in connective tissue, causing a blue-black discolouration. Degenerative arthropathy of the spine, knee, and hip are common signs of ochronosis in older age. An association between ochronosis and depression has not previously been discussed in the literature. This case report describes a 69 year-old woman with diabetes mellitus, ochronosis, depression and chronic pain. |
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