Preserved synaptic vesicle recycling in hippocampal neurons in a mouse Alzheimer's disease model |
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Authors: | Yao Pamela J Bushlin Ittai Furukawa Katsutoshi |
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Affiliation: | Laboratory of Neurosciences, NIA/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. yaopa@grc.nia.nih.gov |
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Abstract: | A recently described triple-transgenic mouse model (3xTg, PS1(M146V), APP(Swe), and tau(P301L)) develops a neuropathology similar to the brains of Alzheimer's disease patients including progressive deposits of plaques and tangles [Neuron 39 (2003) 409]. These mice also show age-related deficits in hippocampal synaptic plasticity that occurs before the development of plaques and tangles. Here we report unchanged synaptic vesicle recycling, as measured by FM1-43 release, in the hippocampal neurons of the 3xTg mice. Expression levels of presynaptic protein synaptophysin and of proteins involved in synaptic vesicle recycling including AP180, dynamin I, and synaptotagmin I also remain unaffected. These data suggest that the synaptic deficits observed in the 3xTg neurons may not arise from the preserved synaptic vesicle recycling. |
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Keywords: | Alzheimer’s disease Triple-transgenic mouse model Synapse Synaptic vesicle recycling FM1-43 release |
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