Effect of splenin and splenic protein-free extracts on the adenosine deaminase activity in various organs of the rat

It has been shown that the adenosine deaminase activity of intact rats increases in such lymphoid organs as the thymus and spleen under the influence of splenic protein-free extracts dissolved in the ratio of 1:100. The enzyme activity in testes does not change but its decrease (by 26.2%) is observed in the adrenal glands under the influence of the splenic protein-free extract. An analogous effect is revealed in splenin and its fractions. The splenic protein-free extract increases (by 83%) the enzyme activity in the thymus of splenectomized rats as compared to intact animals but does not change it in a homogenate of testes.