Influence of isoproterenol on net potassium uptake in whole pigeon erythrocytes in vitro期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Influence of isoproterenol on net potassium uptake in whole pigeon erythrocytes in vitro

Authors:	Draginja Peričin Svetlana Trivić Vladimir Leskovac

Institution:	1. Faculty of Technology, University of Novi Sad, 21000 Novi Sad, Yugoslavia;2. Faculty of Sciences, University of Novi Sad, 21000 Novi Sad, Yugoslavia

Abstract:	Isoproterenol increases net uptake of potassium in whole pigeon erythrocytes $in vitro$ ; effect of 10^?5 M isoproterenol is blocked by 10^?4 M propranolol. Pentifylline, a potent inhibitor of cAMP-phosphodiesterase, significantly amplifies effect of isoproterenol, indicating that isoproterenol-effect is mediated by cAMP. cAMP alone has no direct influence on net potassium uptake, while dibuturyl-cAMP has a very weak effect. Isoproterenol-effects are also mediated by the cell membrane protein-phosphorylation.

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